Reaction: lipoyl synthase List of reactions

Reaction name: lipoyl synthase Reaction type: cognate
EC number:2.8.1.8 Kegg ID:R07767 Rhea ID:16588
Directionality: reversible Curation status: valid Classification: public
Description:This reaction represents the final step in the de-novo biosynthesis of the lipoyl cofactor
Curator notes:

Substrate

ID Type Compound ID Name Stoichiometry Curator notes
chebi 29917 thiol group 1
chebi 59789 S-adenosyl-L-methionine zwitterion 2
chebi 78809 N(6)-octanoyl-L-lysine residue 1
chebi 33738 di-mu-sulfido-diiron(1+) 2

Product

ID Type Compound ID Name Stoichiometry Curator notes
chebi 64428 H group 2
chebi 17319 5'-deoxyadenosine 2
chebi 83099 N(6)-[(R)-lipoyl]-L-lysine residue 1
chebi 57844 L-methionine zwitterion 2
chebi 33737 di-mu-sulfido-diiron(2+) 2

Schemes

# Name
130 lipoyl synthase, radical SAM superfamily

Reaction

lipoyl synthase

+ 2 + + 2 2 + 2 + + 2 + 2
thiol group
29917		 S-adenosyl-L-methionine zwitterion
59789		 N(6)-octanoyl-L-lysine residue
78809		 di-mu-sulfido-diiron(1+)
33738		 H group
64428		 5'-deoxyadenosine
17319		 N(6)-[(R)-lipoyl]-L-lysine residue
83099		 L-methionine zwitterion
57844		 di-mu-sulfido-diiron(2+)
33737

EC: 2.8.1.8 | IntEnz: 2.8.1.8 | Kegg: 2.8.1.8 | BioCyc: 2.8.1.8 | BRENDA: 2.8.1.8