Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup SPASM/twitch domain containing
⌊ Family neomycin C-like epimerase
Total |
100% ![]() |
<100% ![]() |
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Functional domains | 4 | 4 | 0 | ||
UniProtKB | 4 | 4 | 0 | ||
GI | 11 | 11 | 0 | ||
Structures | 0 | ||||
Reactions | 1 | ||||
Functional domains of this family were last updated on June 10, 2017 | |||||
New functional domains were last added to this family on July 5, 2014 |
The last step of neomycin biosynthesis is the epimerization at C-5''' of neomycin C to give neomycin B. This step is catalyzed by NeoN (originally deposited as NeoH), a radical SAM epimerase.
Kudo F, Hoshi S, Kawashima T, Kamachi T, Eguchi T
Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis
▸ Abstract
J Am Chem Soc 2014;136(39):13909-13915 | PubMed ID: 25230155
There is a suggested mechanism for this family.
Static File Downloads
File Name | Description | Parameters | Stats |
---|---|---|---|
network.fam546.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 9.6K num_edges = 6 num_nodes = 4 |
sfld_alignment_fam546.msa | Annotated Sequence Alignment, Stockholm format | 3 sequences size: 2.3K |