Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup anaerobic coproporphyrinogen-III oxidase like
⌊ Family cyclopropanase
| Total |
100%  |
<100% |
|||
| Functional domains | 18 | 18 | 0 | ||
| UniProtKB | 63 | 63 | 0 | ||
| GI | 117 | 117 | 0 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on June 10, 2017 | |||||
| New functional domains were last added to this family on July 5, 2014 | |||||
Jaw5 is thought to perform several sequential cyclopropanation reactions during the modification of the polyketide chain of Jawsamycin. The polyketide chain of is grown consecutively, and Jaw5 is thought to work on the chain as it grows.
The mechanism is proposed to proceed via a SAM ylide intermediate, which acts as the methyl donor to form the cyclopropane ring. The SAM is thought to be utilized in a stoichiometric manner.
Hiratsuka T, Suzuki H, Kariya R, Seo T, Minami A, Oikawa H
Biosynthesis of the structurally unique polycyclopropanated polyketide-nucleoside hybrid jawsamycin (FR-900848)
▸ Abstract
Angew Chem Int Ed Engl 2014;53(21):5423-5426 | PubMed ID: 24756819
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam545.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 113K num_edges = 153 num_nodes = 18 |
| sfld_alignment_fam545.msa | Annotated Sequence Alignment, Stockholm format | 18 sequences size: 11K |
