Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup SPASM/twitch domain containing
⌊ Family cytosylglucuronate decarboxylase
| Total |
100%  |
<100% |
|||
| Functional domains | 5 | 5 | 0 | ||
| UniProtKB | 4 | 4 | 0 | ||
| GI | 6 | 6 | 0 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on June 10, 2017 | |||||
| New functional domains were last added to this family on June 22, 2014 | |||||
BlsE, the first enzyme characterized in this family, is a SAM-dependent radical enzyme that utilizes cytosylglucuronic acid, the accumulated intermediate metabolite in blsE mutant, as substrate and catalyzes decarboxylation at the C5 position of the glucoside residue to yield cytosylarabinopyranose.
Feng J, Wu J, Dai N, Lin S, Xu HH, Deng Z, He X
Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway
▸ Abstract
PLoS One 2013;8(7):None-None | PubMed ID: 23874663
Mutagenesis studies demonstrated that Cys31, Cys35, Cys38 are in the C×××C×MC motif and Gly73, Gly74, Glu75, Pro76 aid in binding SAM. Similarity to NirJ proposed based on 35% amino acid similarity to demonstrate possible similar reactions.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam517.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 13K num_edges = 10 num_nodes = 5 |
| sfld_alignment_fam517.msa | Annotated Sequence Alignment, Stockholm format | 7 sequences size: 3.8K |
