Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup anaerobic coproporphyrinogen-III oxidase like

  ⌊ methyltransferase (class C)

     ⌊ Family 3-methyl-2-indolic acid methyltransferase (NocN/NosN like)

Total 100% <100%
Functional domains 3 3 0
UniProtKB 3 3 0
GI 3 3 0
Structures 0
Reactions 2
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on July 20, 2012

NocN shares 75% sequence identity with NosN and thus, is thought to have a very similar function. NosN shares high sequence similarity to various putative methyltransferases with a radical S-AdoMet-dependent manner, including Tlm-Orf11 (32% identity) in tallysomycin biosynthesis. Experimental characterisation shows that NosN functions as a methyltransferase and acts on the 3-methylindolyl group (product of the NosL enzyme's reaction) at the C-4 position for furnishing the 3,4-dimethylindolyl moiety.

Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W

Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework

▸ Abstract

ACS Chem Biol 2009;4(10):855-864 | PubMed ID: 19678698

Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W

Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099

▸ Abstract

Mol Biosyst 2010;6(7):1180-1185 | PubMed ID: 20473441

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam434.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K		 size = 5.9K
num_edges = 3
num_nodes = 3
sfld_alignment_fam434.msa Annotated Sequence Alignment, Stockholm format 2 sequences
size: 2.4K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

nosiheptide methyltransferase

+ 2 + + +
3-methylindolyl precursor of nosiheptide
85713		 S-adenosyl-L-methionine zwitterion
59789		 3,4-dimethylindolyl precursor of nosiheptide
85714		 5'-deoxyadenosine
17319		 L-methionine zwitterion
57844		 S-adenosyl-L-homocysteine zwitterion
57856

EC: 2.1.1.- | IntEnz: 2.1.1.- | Kegg: 2.1.1.- | BioCyc: 2.1.1.- | BRENDA: 2.1.1.- |

3-methyl-2-indolic acid methyltransferase

+ 2 + + +
3-methyl-2-indolate
85502		 S-adenosyl-L-methionine zwitterion
59789		 3,4-dimethylindole-2-carboxylate
87160		 S-adenosyl-L-homocysteine zwitterion
57856		 L-methionine zwitterion
57844		 5'-deoxyadenosine
17319

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |