Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup AviX12-like
⌊ Family avilamycin epimerase
| Total |
100%  |
<100% |
|||
| Functional domains | 3 | 3 | 0 | ||
| UniProtKB | 3 | 3 | 0 | ||
| GI | 7 | 7 | 0 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on June 10, 2017 | |||||
| New functional domains were last added to this family on July 5, 2014 | |||||
The biosynthesis of avilamycin, an oligosaccharide antibiotic, starts with the formation of a disaccharide synthesised from d-glucose. AviX12 is involved in C-2 epimerization of the glucose moiety after the whole avilamycin molecule has been formed to form the d-mannose stereoisomer. Unusually, the C-2 carbon is an uncativated centre, and it is thought that AviX12 generates the 5'deoxyadenosyl radical, which abstracts a hydrogen atom a position C-2 of the mannose moiety to form a radical intermediate. This intermediate undergoes epimerization by an unknown mechanism.
Boll R, Hofmann C, Heitmann B, Hauser G, Glaser S, Koslowski T, Friedrich T, Bechthold A
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme
▸ Abstract
J Biol Chem 2006;281(21):14756-14763 | PubMed ID: 16537546
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam421.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 6.4K num_edges = 3 num_nodes = 3 |
| sfld_alignment_fam421.msa | Annotated Sequence Alignment, Stockholm format | 2 sequences size: 2.1K |
