Top Level Name
⌊ Superfamily (core) Radical SAM
⌊ Subgroup F420, menaquinone cofactor biosynthesis
⌊ menaquinone synthsis involved
⌊ Family aminofutalosine synthase (mqnE-like)
| Total |
100%  |
<100% |
|||
| Functional domains | 534 | 534 | 0 | ||
| UniProtKB | 524 | 524 | 0 | ||
| GI | 1264 | 1264 | 0 | ||
| Structures | 0 | ||||
| Reactions | 1 | ||||
| Functional domains of this family were last updated on June 22, 2017 | |||||
| New functional domains were last added to this family on June 22, 2014 | |||||
Members of this family are involved in the biosynthesis of aminofutalosine, a key intermediate in the formation of menaquinone (vitamin K2), from chorismate. It is proposed that the SAM molecule is utilized stoichiometrically in the mechanism (see PMID: 24083939). Other than the SAM binding cysteine residues, the full complement of catalytic residues remains to be elucidated.
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T
An alternative menaquinone biosynthetic pathway operating in microorganisms
▸ Abstract
Science 2008;321(5896):1670-1673 | PubMed ID: 18801996
Mahanta N, Fedoseyenko D, Dairi T, Begley TP
Menaquinone Biosynthesis: Formation of Aminofutalosine Requires a Unique Radical SAM Enzyme
▸ Abstract
J Am Chem Soc 2013;135(41):15318-15321 | PubMed ID: 24083939
No notes.
Static File Downloads
| File Name | Description | Parameters | Stats |
|---|---|---|---|
| network.fam343.bs60.mek250K.xgmml | One node per sequence network | min bit score = 60 max edge count = 250K |
size = 74M num_edges = 142311 num_nodes = 534 |
| sfld_alignment_fam343.msa | Annotated Sequence Alignment, Stockholm format | 335 sequences size: 187K |
