Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup F420, menaquinone cofactor biosynthesis

  ⌊ menaquinone synthsis involved

     ⌊ Family cyclic dehypoxanthine futalosine synthase (mqnC-like)

Total 100% <100%
Functional domains 897 896 1
UniProtKB 1260 1259 1
GI 2757 2754 3
Structures 0
Reactions 1
Functional domains of this family were last updated on June 10, 2017
New functional domains were last added to this family on June 22, 2014

In microorganisms, menaquinone is an obligatory component of the electron-transfer pathway. Whilst the many organisms (e.g. E. coli) derive menaquinone via chorismtae, some microorganisms (including pathogenic species such as Helicobacter pylori and Campylobacter jejuni) do onto contain orthologues to these genes, despite synthesizing menaquinone. Thus, an alternative pathway has been deduced in which proteins from this family are involved in menaquinone biosynthesis via futalosine. The proposed mechanism (see PMID:23763543) suggests that the SAM is stoichiometric in this reaction.

Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T

An alternative menaquinone biosynthetic pathway operating in microorganisms

▸ Abstract

Science 2008;321(5896):1670-1673 | PubMed ID: 18801996

Cooper LE, Fedoseyenko D, Abdelwahed SH, Kim SH, Dairi T, Begley TP

In Vitro Reconstitution of the Radical S-Adenosylmethionine Enzyme MqnC Involved in the Biosynthesis of Futalosine-Derived Menaquinone

▸ Abstract

Annu Rev Biochem 2013;52(27):4592-4594 | PubMed ID: 23763543

No notes.

Static File Downloads

File Name Description Parameters Stats
network.fam342.bs60.mek250K.xgmml One node per sequence network min bit score = 60
max edge count = 250K		 size = 129M
num_edges = 250000
num_nodes = 897
sfld_alignment_fam342.msa Annotated Sequence Alignment, Stockholm format 322 sequences
size: 151K

Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Catalyzed Reaction(s)

cyclic dehypoxanthinyl futalosine synthase

+ + + +
S-adenosyl-L-methionine zwitterion
59789		 dehypoxanthine futalosinate
58864		 5'-deoxyadenosine
17319		 L-methionine zwitterion
57844		 cyclic dehypoxanthinylfutalosinate(1-)
64270		 hydron
15378

EC: 1.21.98.1 | IntEnz: 1.21.98.1 | Kegg: 1.21.98.1 | BioCyc: 1.21.98.1 | BRENDA: 1.21.98.1