Top Level Name

  ⌊ Superfamily (core) Radical SAM

    ⌊ Subgroup anaerobic coproporphyrinogen-III oxidase like

  ⌊ FunctionalDomain uncharacterized anaerobic coproporphyrinogen-III oxidase-like sequence (ID 380963)

Superfamily Assignment Evidence Code(s) IEA
This entry was last updated onJune 10, 2017

References to Other Databases

Genbank

SpeciesGIAccessionProteome
Synechocystis sp. PCC 6803 Taxon ID: 1148 499175254 WP_010872841.1 (RefSeq) URP
Synechocystis sp. PCC 6803 Taxon ID: 1148 451780937 AGF51906.1 (Genbank) URP
Bacillus subtilis BEST7613 Taxon ID: 1204343 407961832 URP
Show All

Uniprot

Protein NameAccessionEC Number Identifier
Oxygen-independent coproporphyrinogen III oxidase P74132 HEMN_SYNY3 (Swiss-Prot)

Sequence

Length of Enzyme (full-length): 466 | Length of Functional Domain: 463

1       10        20        30        40        50        60

MTTTFPTVEFSAELLNKYNQGIPRYTSYPPATELNKEFDPSDFQTAINLGNYKKTPLSLY
CHIPFCAKACYFCGCNTIITQHKPAVDPYLKAVAKQIALVAPLVDQQRPVQQLHWGGGTP
NYLTLEQAEFLFNTITDAFPLAENAEISIEINPCYVDKDYIFALRQLGFNRISFGIQDFN
SQVQQAVNRIQPEAMLFQVMDWIRQANFDSVNVDLIYGLPHQNLATFRETLRKTAQLNPD
RIAVFNFAYVPWLKPVQKKMPESALPPAEEKLKIMQATIADLTEQGYVFIGMDHFAKPDD
ELAIAQRRGELHRNFQGYTTQPESDLLGFGITSISMLQDVYAQNHKTLKAFYNALDREVM
PIEKGFKLSQDDLIRRTVIKELMCQFKLSAQELESKYNLGFDCDFNDYFAKELSALDVLE
ADGLLRRLGDGLEVTPRGRILIRNIAAVFDTYLQNKSKQQMFSRAI
This shows the full-length sequence of the enzyme. The region of the functional domain is highlighted in black letters, while the residual residues are shown in grey. The Superfamily domain, when present, is shown using underlining. In many cases the functional domain is the full-length sequence.
Conserved catalytic residues (as determined by automated alignment to family, subgroup, or superfamily HMMs) are shown with teal highlighting . Conserved catalytic residues which do not matched the Conserved Alignment Residue are shown with maroon highlighting . Information regarding their function can be found in the Conserved Residues section below.
FASTA formatted full-length sequence.
BLAST this sequence against SFLD.
Scan SFLD-HMMs with this sequence.

Conserved Residues
Superfamily CAR This EFD conserves 3/3 Superfamily-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
66 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
70 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
73 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
Subgroup CAR This EFD conserves 3/3 Subgroup-specific Conserved Alignment Residues.
Position Amino Acid Location Function Role Evidence Code Reference
66 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
70 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS
73 Cys (C) side chain Binds [4Fe-4S]-AdoMet cluster cofactor binding -- binding ISS

Catalyzed Reaction

coproporphyrinogen dehydrogenase

2 + 2 + 2 + 2 +
S-adenosyl-L-methionine zwitterion
59789		 coproporphyrinogen III(4-)
57309		 5'-deoxyadenosine
17319		 L-methionine zwitterion
57844		 carbon dioxide
16526		 protoporphyrinogen(2-)
57307

EC: 1.3.99.22 | IntEnz: 1.3.99.22 | Kegg: 1.3.99.22 | BioCyc: 1.3.99.22 | BRENDA: 1.3.99.22

Curation History
Time Change Annotation Old Value New Value
May 14, 2014, 3:30 a.m. update curation agent holliday setDomainBoundaries.py
update domain start position 1 5
May 11, 2015, 11:36 a.m. update curation agent setDomainBoundaries.py holliday
update curation agent holliday setDomainBoundaries.py
June 12, 2015, 4:59 p.m. update curation agent setDomainBoundaries.py holliday
remove family assignment evidence code ISS -
remove family oxygen-independent coproporphyrinogen-III oxidase 1 (HemN-like) -
update name Oxygen-independent coproporphyrinogen-III oxidase uncharacterized anaerobic coproporphyrinogen-III oxidase-like sequence
update superfamily assignment evidence code ISS IEA
June 12, 2015, 4:59 p.m. update curation agent holliday setDomainBoundaries.py
update domain start position 5 4
EC number assigned by UniProtKB accession ID.