Top Level Name
⌊ Superfamily (core) Isoprenoid Synthase Type I
|Functional domains of this superfamily were last updated on March 22, 2017|
|New functional domains were last added to this superfamily on Aug. 2, 2014|
The conserved chemistry of the Isoprenoid Synthase Type I superfamily involves the formation of a carbocation by release of a pyrophosphate group. A common DDXXD sequence motif is used to bind the diphosphate moiety of substrates via Mg2+, facilitating pyrophosphate release. Members share a common fold, termed the terpenoid synthase fold in SCOP. Many characterized enzymes in this superfamily are known to be promiscuous. Note: Some enzymes in this superfamily may also have a domain that is a member of the Isoprenoid Synthase Type II superfamily.
Structural biology and chemistry of the terpenoid cyclases
Sequence Similarity Networks
Download a Sequence Similarity Network of this superfamily (XGMML format ).
Network downloads are XGMML files that are readable by program such as Cytoscape. In these networks, nodes represent proteins and edges represent pairwise similarities better than a given bitscore cutoff. Additionally, these networks contain several attributes with data from the SFLD.
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|Maximum number of edges:|
Repnet: 50% ID (1-Apr-2016)
Multiple Sequence Alignment
Multiple Sequence Alignment
Some of these files can be quite large, please be patient during the download.
The maximum bitscore at which pairwise similarities are included in the network.
Open in Cytoscape via:
→Network (multiple file types)
Full length sequences in FASTA format.
Sequences of the Functional Domain in FASTA format.
Download complete annotation of sequences sets of this superfamily as a ͟Tab ͟Separated ͟Value (TSV) file. This file has all data but cell size can exceed the maximum supported by spreadsheet programs (such as Microsoft Excel ®).
Annotation of sequences sets of this superfamily in a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application. Cells which exceed the allowed spreadsheet maximum (32.5K) are preceded by the word "Truncated" and clipped short.
|Subgroup ▸ Legend||T||K||C||U||S|
|┗ Level: Subgroup||T||K||c||S|
|Competence Regulatory Protein ComQ||336||0||0||336||0|
|Polyprenyl Transferase Like||9598||0||0||9598||244|
|Squalene/Phytoene Synthase Like||3187||36||0||3151||54|
|┗ dehydrosqualene synthase||9||9||0||26|
|┗ squalene synthase||27||27||0||25|
|┗ 1: Phytoene synthase like||2032||0||0||2032||2|
|Terpene Cyclase Like 1 C Terminal Domain||1520||0||0||1520||40|
|Terpene Cyclase Like 2||932||0||0||932||39|
|Trichodiene Synthase Like||216||43||0||173||20|
|┗ trichodiene synthase||43||43||0||20|