Top Level Name
⌊ Superfamily (core) RuBisCO
Family known ![]() |
|||||||
Total |
100% ![]() |
<100% ![]() |
Family unknown ![]() |
||||
Functional domains | 42603 | 581 | 1 | 42021 | |||
UniProtKB | 49386 | 758 | 0 | 48628 | |||
GI | 62817 | 1960 | 7 | 60850 | |||
Structures | 74 | ||||||
Reactions | 0 | ||||||
Functional domains of this superfamily were last updated on Nov. 22, 2017 | |||||||
New functional domains were last added to this superfamily on March 23, 2015 |
Structurally characterized enzymes in the RuBisCO superfamily are dimers with an active site located at the interface of the N-terminal alpha+beta domain of one polypeptide and the C-terminal TIM beta/alpha-barrel of the second polypeptide. Though most of the enzymes in the superfamily are thought to function as D-Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO), a smaller number of enzymes, termed the RuBisCO-like proteins, do not catalyze carboxylation reactions. Despite these differences, superfamily enzymes share a common active site architecture used to stabilize an enolate intermediate.
Imker HJ, Singh J, Warlick BP, Tabita FR, Gerlt JA
Mechanistic Diversity in the RuBisCO Superfamily: A Novel Isomerization Reaction Catalyzed by the RuBisCO-like Protein from Rhodospirillum rubrum
▸ Abstract
Biochemistry 2008;47(43):11171-11173 | PubMed ID: 18826254
Taylor TC, Andersson I
The structure of the complex between rubisco and its natural substrate ribulose 1,5-bisphosphate
▸ Abstract
J Mol Biol 1997;265(4):432-444 | PubMed ID: 9034362
No notes.
Sequence Similarity Networks
Download a Sequence Similarity Network of this superfamily
(XGMML format ).
Network downloads are XGMML files that are readable by program such as Cytoscape. In these networks, nodes represent proteins and edges represent pairwise similarities better than a given edge-score cutoff. The edge score is either a bit score for full networks or mean E values for a Repnet. Additionally, these networks contain several attributes with data from the SFLD.
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List of files included in the download. A detailed list of included node attributes, their definitions, and their uses [revised: 1/24/2014].
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Multiple Sequence Alignment
Multiple Sequence Alignment
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The least significant edge-score at which pairwise similarities are included in the network. A bit score for the full network, or a mean E value for the Repnet.
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Full length sequences in FASTA format.
Sequences of the Functional Domain in FASTA format.
Download complete annotation of sequences sets of this superfamily as a ͟Tab ͟Separated ͟Value (TSV) file. This file has all data but cell size can exceed the maximum supported by spreadsheet programs (such as Microsoft Excel ®).
Annotation of sequences sets of this superfamily in a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application. Cells which exceed the allowed spreadsheet maximum (32.5K) are preceded by the word "Truncated" and clipped short.
Subgroup ▸ Legend | T ![]() |
K ![]() |
C ![]() |
U ![]() |
S ![]() |
||
---|---|---|---|---|---|---|---|
RuBisCO | 25157 | 0 | 0 | 25157 | 57 | ||
RuBisCO-like proteins | 1147 | 582 | 581 | 565 | 12 | ||
┗ 2,3-diketo-5-methylthiopentyl-1-phosphate enolase | 508 | 508 | 507 | 6 | |||
┗ 5-methylthio-D-ribulose 1-phosphate isomerase | 74 | 74 | 74 | 1 |