Top Level Name

  ⌊ Superfamily (core) Enolase

    ⌊ Subgroup muconate cycloisomerase

  muconate cycloisomerase (syn) like

Family known
Total 100% <100% Family unknown
Functional domains 1525 0 0 1525
UniProtKB 2660 0 0 2660
GI 5163 0 0 5163
Structures 13
Reactions 0
Functional domains of this subgroup were last updated on Nov. 22, 2017
New functional domains were last added to this subgroup on Sept. 14, 2015

The muconate cycloisomerase (syn) like subgroup contains experimentally characterized enzymes that catalyze the cycloisomerization of muconate and/or muconate-like substrates with additional substituents, such as chlorine, in various positions. Depending on the enzyme, these chlorinated substrates may be dechlorinated along with the cycloisomerization, or not. Many of these enzymes are involved in the beta-ketoadipate pathway, or derivatives thereof. Note that this group does not contain the muconate cycloisomerases that catalyze anti-cycloisomerization of muconate.

Schell U, Helin S, Kajander T, Schlomann M, Goldman A

Structural basis for the activity of two muconate cycloisomerase variants toward substituted muconates

▸ Abstract

Proteins 1999;34(1):125-136 | PubMed ID: 10336378

Kajander T, Lehtio L, Schlomann M, Goldman A

The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function

▸ Abstract

Protein Sci 2003;12(9):1855-1864 | PubMed ID: 12930985

Sakai A, Fedorov AA, Fedorov EV, Schnoes AM, Glasner ME, Brown S, Rutter ME, Bain K, Chang S, Gheyi T, Sauder JM, Burley SK, Babbitt PC, Almo SC, Gerlt JA

Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes

▸ Abstract

Biochemistry 2009;48(7):1445-1453 | PubMed ID: 19220063

Cámara B, Nikodem P, Bielecki P, Bobadilla R, Junca H, Pieper DH

Characterization of a gene cluster involved in 4-chlorocatechol degradation by Pseudomonas reinekei MT1

▸ Abstract

J Bacteriol 2009;191(15):4905-4915 | PubMed ID: 19465655

No notes.

Sequence Similarity Networks

Download a Sequence Similarity Network of this subgroup (XGMML format ).

Network downloads are XGMML files that are readable by program such as Cytoscape. In these networks, nodes represent proteins and edges represent pairwise similarities better than a given edge-score cutoff. The edge score is either a bit score for full networks or mean E values for a Repnet. Additionally, these networks contain several attributes with data from the SFLD.

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List of files included in the download. A detailed list of included node attributes, their definitions, and their uses [revised: 1/24/2014].

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Multiple Sequence Alignment

View the alignment of a representative set of sequences of this subgroup using

Multiple Sequence Alignment

Align one or multiple sequences to the alignment of a representative set of sequences of this subgroup.
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Data Type All (#) Known (#) Unknown (#)
Full length FASTA (1525) (0) (1525)
Complete annotation (.tsv) (1525) (0) (1525)
Annotation suitable for Excel ® (.tsv) (1525) (0) (1525)
Clear form

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To identify your sequence later, please make sure to provide a header line starting with '>' for each sequence. Empty headers are allowed, but a header line is always required.
Cutoff Value
The least significant edge-score at which pairwise similarities are included in the network. A bit score for the full network, or a mean E value for the Repnet.
XGMML format
Open in Cytoscape via:
 →Network (multiple file types)
Download the annotation of all sequences as shown in the table below as a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application.
Full length FASTA
Full length sequences in FASTA format.
Functional Domain FASTA
Sequences of the Functional Domain in FASTA format.
Complete annotation
Download complete annotation of sequences sets of this superfamily as a ͟Tab ͟Separated ͟Value (TSV) file. This file has all data but cell size can exceed the maximum supported by spreadsheet programs (such as Microsoft Excel ®).
Spreadsheet ready annotation
Annotation of sequences sets of this superfamily in a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application. Cells which exceed the allowed spreadsheet maximum (32.5K) are preceded by the word "Truncated" and clipped short.
Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T K C U S
┗ 1: muconate cycloisomerase (syn) like 1525 0 0 1525 13
Depth of the multi-level Subgroup hierarchy.