Top Level Name

  ⌊ Superfamily (core) Glutathione Transferase (cytosolic)

    ⌊ Subgroup Main (cytGST)

  Main.4: Theta-like

Total 100% <100% Family unknown
Functional domains 806
UniProtKB 866 0 0 866
GI 1740 0 0 1740
Structures 35
Reactions 0
Functional domains of this subgroup were last updated on June 10, 2017
New functional domains were last added to this subgroup on June 22, 2012

Cytosolic GSTs that include proteins with "Theta" Swiss-Prot family annotations. Proteins in this subgroup are known to catalyze the following reaction types: conjugate addition, epoxide ring opening, hydrolytic dehalogenation, nucleophilic addition, nucleophilic aromatic substitution, nucleophilic substitution (SN2), peroxidase, and thiolysis reactions. For example, SFLD protein 55995 (UniProt accn P20432) has experimentally-confirmed conjugate addition activity with ethacrynic acid; nucleophilic aromatic substitution activity with CDNB and DCNB (dichloronitrobenzene); and peroxidase activity with 4-hydroperoxy-2-nonenal. It additionally has DDT-dehydrochlorinase activity with the synthetic pesticide and environmental pollutant DDT.

No References.

No notes.

Sequence Similarity Networks

Download a Sequence Similarity Network of this subgroup (XGMML format ).

Network downloads are XGMML files that are readable by program such as Cytoscape. In these networks, nodes represent proteins and edges represent pairwise similarities better than a given edge-score cutoff. The edge score is either a bit score for full networks or mean E values for a Repnet. Additionally, these networks contain several attributes with data from the SFLD.

No edge data is available for this network. Contact an SFLD curator to request this network.

List of files included in the download. A detailed list of included node attributes, their definitions, and their uses [revised: 1/24/2014].

Although the download speed has improved please keep in mind that network files can be quite large. We are currently working on improving the network download and finding ways to make large networks manageable. Please see How to increase memory for Cytoscape.

Multiple Sequence Alignment

View the alignment of a representative set of sequences of this subgroup using

Multiple Sequence Alignment

Align one or multiple sequences to the alignment of a representative set of sequences of this subgroup.
Enter FASTA formatted sequence(s) : and view results using


Data Type All (#) Known (#) Unknown (#)
Full length FASTA (806) (0) (806)
Complete annotation (.tsv) (806) (0) (806)
Annotation suitable for Excel ® (.tsv) (806) (0) (806)
Clear form

Some of these files can be quite large, please be patient during the download.

To identify your sequence later, please make sure to provide a header line starting with '>' for each sequence. Empty headers are allowed, but a header line is always required.
Cutoff Value
The least significant edge-score at which pairwise similarities are included in the network. A bit score for the full network, or a mean E value for the Repnet.
XGMML format
Open in Cytoscape via:
 →Network (multiple file types)
Download the annotation of all sequences as shown in the table below as a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application.
Full length FASTA
Full length sequences in FASTA format.
Functional Domain FASTA
Sequences of the Functional Domain in FASTA format.
Complete annotation
Download complete annotation of sequences sets of this superfamily as a ͟Tab ͟Separated ͟Value (TSV) file. This file has all data but cell size can exceed the maximum supported by spreadsheet programs (such as Microsoft Excel ®).
Spreadsheet ready annotation
Annotation of sequences sets of this superfamily in a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application. Cells which exceed the allowed spreadsheet maximum (32.5K) are preceded by the word "Truncated" and clipped short.
Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues
Subgroup ▸ Legend T S
┗ 1: Main.4: Theta-like 806 35
Depth of the multi-level Subgroup hierarchy.