Reaction: acireductone synthase List of reactions

Reaction name: acireductone synthase Reaction type: cognate
EC number: Kegg ID:R07395 Rhea ID:21703
Directionality: reversible Curation status: valid Classification: public
Description:This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (EC 5.3.2.5), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one (EC 3.1.3.87).
Curator notes:The acireductone represents a branch point in the methione-salvage pathway as it is used in the formation of formate, CO and 3-(methylthio)propanoate by EC 1.13.11.53 [acireductone dioxygenase (Ni2+-requiring)] and of formate and 4-methylthio-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54 {acireductone dioxygenase [iron(II)-requiring]}
ID Type Compound ID Name Stoichiometry Curator notes
chebi 58828 5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-) 1
chebi 15377 water 1
ID Type Compound ID Name Stoichiometry Curator notes
chebi 49252 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one 1
chebi 43474 hydrogenphosphate 1

Reaction

acireductone synthase

+ +
5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-)
58828
water
15377
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
49252
hydrogenphosphate
43474

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