Reaction: gentamicin N-methyltransferase List of reactions

Reaction name: gentamicin N-methyltransferase Reaction type: cognate
EC number: Kegg ID: Rhea ID:
Directionality: reversible Curation status: valid Classification: public
Description:The first methylation in the conversion of gentamicin A2 to gentamycin X2.
Curator notes:The roles of the two SAM molecules have been inferred given the membership of proteins performing this reaction to the B12-dependent methyltransferases (Radical SAM Superfamily, Class B Methylatransferase Family).
ID Type Compound ID Name Stoichiometry Curator notes
chebi 81279 Gentamicin A2 1
chebi 59789 S-adenosyl-L-methionine zwitterion 2
ID Type Compound ID Name Stoichiometry Curator notes
chebi 28418 gentamycin A 1 This is the singly methylated precursor to gentamycin X2
chebi 57856 S-adenosyl-L-homocysteine zwitterion 1
chebi 57844 L-methionine zwitterion 1
chebi 17319 5'-deoxyadenosine 1

Reaction

gentamicin N-methyltransferase

+ 2 + + +
Gentamicin A2
81279
S-adenosyl-L-methionine zwitterion
59789
gentamycin A
28418
S-adenosyl-L-homocysteine zwitterion
57856
L-methionine zwitterion
57844
5'-deoxyadenosine
17319

EC: | IntEnz: | Kegg: | BioCyc: | BRENDA: |