Reaction: coproporphyrinogen dehydrogenase List of reactions

Reaction name: coproporphyrinogen dehydrogenase Reaction type: cognate
EC number:1.3.99.22 Kegg ID:R06895 Rhea ID:15428
Directionality: reversible Curation status: valid Classification: public
Description:This reaction differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion replaces the electron initially used.
Curator notes:
ID Type Compound ID Name Stoichiometry Curator notes
chebi 59789 S-adenosyl-L-methionine zwitterion 2
chebi 57309 coproporphyrinogen III(4-) 1
ID Type Compound ID Name Stoichiometry Curator notes
chebi 17319 5'-deoxyadenosine 2
chebi 57844 L-methionine zwitterion 2
chebi 16526 carbon dioxide 2
chebi 57307 protoporphyrinogen(2-) 1

Reaction

coproporphyrinogen dehydrogenase

2 + 2 + 2 + 2 +
S-adenosyl-L-methionine zwitterion
59789
coproporphyrinogen III(4-)
57309
5'-deoxyadenosine
17319
L-methionine zwitterion
57844
carbon dioxide
16526
protoporphyrinogen(2-)
57307

EC: 1.3.99.22 | IntEnz: 1.3.99.22 | Kegg: 1.3.99.22 | BioCyc: 1.3.99.22 | BRENDA: 1.3.99.22