Top Level Name

  ⌊ Superfamily (core) Enolase

    ⌊ Subgroup enolase

     ⌊ Family enolase

Total 100% <100%
Functional domains 13530 0 13530
UniProtKB 28511 0 28511
GI 53656 0 53656
Structures 60
Reactions 1
Functional domains of this family were last updated on Nov. 22, 2017
New functional domains were last added to this family on May 7, 2015

Enzymes in the enolase family catalyze the dehydration of 2-phosphoglycerate to form phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. Due to the ubiquitous nature of these pathways, the enolase family is quite large. Enzymes in the enolase family require an additional divalent metal ion, beyond the one divalent metal required across all enzymes in the superfamily, for optimal activity.

No References.

No notes.

Sequence Similarity Networks

Download a Sequence Similarity Network of this family (XGMML format ).

Network downloads are XGMML files that are readable by program such as Cytoscape. In these networks, nodes represent proteins and edges represent pairwise similarities better than a given edge-score cutoff. The edge score is either a bit score for full networks or mean E values for a Repnet. Additionally, these networks contain several attributes with data from the SFLD.

No edge data is available for this network. Contact an SFLD curator to request this network.

List of files included in the download. A detailed list of included node attributes, their definitions, and their uses [revised: 1/24/2014].

Disclaimer
Although the download speed has improved please keep in mind that network files can be quite large. We are currently working on improving the network download and finding ways to make large networks manageable. Please see How to increase memory for Cytoscape.

Multiple Sequence Alignment

View the alignment of a representative set of sequences of this family using

Multiple Sequence Alignment

Align one or multiple sequences to the alignment of a representative set of sequences of this family.
Enter FASTA formatted sequence(s) : and view results using

Downloads

Data Type All (#) Known (#)
Full length FASTA (13530) ()
Complete annotation (.tsv) (13530) ()
Annotation suitable for Excel ® (.tsv) (13530) ()
Clear form

Some of these files can be quite large, please be patient during the download.

To identify your sequence later, please make sure to provide a header line starting with '>' for each sequence. Empty headers are allowed, but a header line is always required.
Cutoff Value
The least significant edge-score at which pairwise similarities are included in the network. A bit score for the full network, or a mean E value for the Repnet.
XGMML format
Open in Cytoscape via:
 Menu
 →Import
 →Network (multiple file types)
Download the annotation of all sequences as shown in the table below as a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application.
Full length FASTA
Full length sequences in FASTA format.
Functional Domain FASTA
Sequences of the Functional Domain in FASTA format.
Complete annotation
Download complete annotation of sequences sets of this superfamily as a ͟Tab ͟Separated ͟Value (TSV) file. This file has all data but cell size can exceed the maximum supported by spreadsheet programs (such as Microsoft Excel ®).
Spreadsheet ready annotation
Annotation of sequences sets of this superfamily in a ͟Tab ͟Separated ͟Value (TSV) file. This file can be imported into a spreadsheet application. Cells which exceed the allowed spreadsheet maximum (32.5K) are preceded by the word "Truncated" and clipped short.
Total number of functional domains in this group.
Number of Functional Domains that have been manually or automatically been assigned to a family.
Number of Functional Domains that have not been assigned to a family.
Number of structures available from the PDB for members of this group.
Number of Functional Domains with 100% of Conserved Residues
Number of Functional Domains with less than 100% Conserved Residues

Active Site

Click on the picture to download the Chimera session file for the generated image above.

Catalyzed Reaction(s)

phosphopyruvate hydratase

+
2-phosphonato-D-glycerate(3-)
58289
phosphonatoenolpyruvate
58702
water
15377

EC: 4.2.1.11 | IntEnz: 4.2.1.11 | Kegg: 4.2.1.11 | BioCyc: 4.2.1.11 | BRENDA: 4.2.1.11