See description in Nucleic Acids Res. 2014 Jan 1;42:D521-30
What is the Structure-Function Linkage Database (SFLD)?
- A hierarchical classification of enzymes that relates specific sequence-structure features to specific chemical capabilities
- A collection of tools and data for investigating sequence-structure-function relationships and hypothesizing function
- The analysis and archive site for superfamilies targeted by the Enzyme Function Initiative
How can I use the SFLD?(see the tutorials for examples)
- Classify a sequence using Hidden Markov Models or BLAST search
- Browse superfamilies in the SFLD
- Browse reactions (overall)
- Search for a specific enzyme (by name, sequence database ID, or PDB ID)
- View sequence alignments
- View structures in Chimera
- Download data: sequence sets, multiple alignments, sequence similarity networks...
What makes the SFLD unique?
- Superfamilies are defined by a conserved chemical capability such as a partial reaction, families by a conserved overall reaction (more...)
- Conserved partial reactions are correlated with associated active site similarities
- Large-scale summaries of relationships between and within groups of enzymes are provided as sequence similarity networks