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Instructions Citing SFLD SFLD Staff Curator's Entrance

Welcome to the Structure-Function Linkage Database

What is the SFLD? What makes the SFLD unique?
A database that links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions The SFLD correlates conserved partial reactions associated with active site similarities in all members of a superfamily
Correlates conserved active site residues with specific partial reactions that all members of a superfamily perform Provides the ability to search for related proteins by their partial chemical reactions
What can I use the SFLD for? How can I use the SFLD? (Instructions & Caveats)
Classify a sequence into the nearest superfamily and retrieve the associated sequences, structures, and chemical reactions of even diverse relatives   Browse by superfamily, subgroup, and family
  Browse by reaction (overall)
  Search by enzyme (GI number or name)
Infer function of a sequence by viewing it in the context of curated proteins at the superfamily and family level   Search by reaction (overall or partial)
  Classify a sequence into a superfamily, subgroup, or family


The SFLD is a collaborative project of the Babbitt and Ferrin labs at UCSF. We gratefully acknowledge support from NIH GM60595 and NSF grants DBI-0234768 and DBI-0640476 (to PCB) and NIH RR01081 (to TEF).

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