Welcome to the Structure-Function Linkage Database |
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| What is the SFLD? |
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What makes the SFLD unique? |
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A database that links evolutionarily related sequences and structures from
mechanistically diverse superfamilies
of enzymes to their chemical reactions |
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The SFLD correlates
conserved partial reactions
associated with active site similarities in all members of a superfamily |
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Correlates conserved active site residues with specific
partial reactions
that all members of a superfamily perform
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Provides the ability to search for related proteins by their partial chemical reactions |
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| What can I use the SFLD for? |
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How can I use the SFLD? (Instructions & Caveats) |
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Classify a sequence into the nearest superfamily and retrieve the associated sequences, structures, and chemical reactions of even diverse relatives |
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Browse by superfamily, subgroup, and family
Browse by reaction (overall)
Search by enzyme (GI number or name)
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Infer function of a sequence by viewing it in the context of curated proteins at the superfamily and family level |
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Search by reaction (overall or partial)
Classify a sequence into a superfamily, subgroup, or family |
The SFLD is a collaborative project of the Babbitt and Ferrin labs at UCSF. We gratefully acknowledge support from NIH GM60595 and NSF grants DBI-0234768 and DBI-0640476 (to PCB) and NIH RR01081 (to TEF).
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