Welcome to the Structure-Function Linkage Database

• A database that links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions
• Correlates conserved active site residues with specific partial reactions that all members of a superfamily perform
  (more details)

• The SFLD correlates conserved partial reactions associated with active site similarities in all members of a superfamily
• Provides the ability to search for related proteins by their partial chemical reactions

• Classify a sequence into the nearest superfamily and retrieve the associated sequences, structures, and chemical reactions of even diverse relatives
• Infer function of a sequence by viewing it in the context of curated proteins at the superfamily and family level

• Browse by superfamily, subgroup, and family
• Browse by reaction (overall)
• Search by enzyme (GI number, PDB-ID, or name)
• Search by reaction (overall or partial)
• Classify a sequence into a superfamily, subgroup, or family using Hidden-Markov-Models or a BLAST search.

• 04/06/2008 - PDB search triggers a sequence search if necessary.
• 09/22/2008 - Database can now be searched by PDB ID.
• 10/08/2008 - BLAST search against sequences in SFLD